p73蛋白在食管鳞状细胞癌中的表达及其临床意义

p73 Protein Expression and its Clinical Significance in Esophageal Cancer Tissues

目的 探讨p73蛋白与食管癌临床病理特征的关系及其临床意义。方法 采用免疫组化技术检测 3 7例食管鳞状细胞癌组织、癌旁组织、区域淋巴结和相应正常食管组织中 p73蛋白的表达情况。 结果 3 7例食管癌组织中有 18例 (4 8.6% ) p73蛋白呈过度表达 ,其阳性表达率显著高于相应的癌旁组织、区域淋巴结和正常食管组织 (P <0 .0 5 ) ;食管癌组织中 p73蛋白过表达与食管癌TNM分期、细胞分化程度和病理类型均无明显关系 (P >0 .0 5 )。结论 p73蛋白在食管癌组织中呈高水平表达 ,p73蛋白可能参与了食管癌的发生。

Objective To study p73 protein expression and its significance in tumorgenesis of esophageal cancer.Methods The expression of p73 protein was detected by immunhistochemistry in 37 cases of esophageal tumor tissue,para cancer tissue,regional lymphonode and matched esophageal normal tissue,its correlation to clinical pathologic characteristic of esophageal cancer was explored.Results Overexpression of p73 protein was found in 18/37(48.6%) of esophageal tumor tissues.The positive expression rate of p73 protein in the tumor tissues was significantly higher than in the para cancer tissues,regional lymphonodi and matched esophageal normal tissues( P <0.05).No significant relationship was observed among p73 protein expression and differentiated grades,pathological classification and P TNM stages of the cancer( P >0.05).Conclusion The results suggest that there is an overexpression of p73 protein in esophageal tumor tissues and it may be participate in regulation of the development in esophageal cancer.