不同加碘时间及碘盐浓度变化人群甲状腺功能亢进流行病学研究

Study on epidemiology of hyperthyroidism in different supply time and different concentration of iodized salt

目的 研究不同加碘时间 ,不同碘盐浓度变化人群甲状腺功能亢进 (简称甲亢 )流行病学状况及普遍食盐加碘 (USI)对甲亢发病率的影响。方法 四井子乡为碘营养正常地区 ,加碘时间早 ,USI前后补碘速度增加迅速 ;北台子乡为严重缺碘地区 ,USI前后补碘剂量变化不大 ;龙城乡为缺碘地区 ,加碘时间接近USI。针对 3个地区调查 376 19人。同时检测患者甲状腺功能 ,甲状腺自身抗体、甲状腺B超和尿碘含量。结果 3个地区甲亢总发病率由USI前 4.5 3/10万人年 ( 95 %Cl:1.6～ 11.7)增加到USI后的 2 4.5 3/10万人年 ( 95 %Cl :6 .2～ 36 .8)。加碘后人群甲亢发病率的相对危险度(RR)亦增加。结论 补碘时间早 ,甲亢病例出现早 ;补碘速度提高快 ,补碘剂量增加大 ,甲亢发病率亦随之增高。

Objective To study the influence of iodized salt supply and the different concentrations of iodized salts on epideniology of hyperthyroidism and the influence of universal salt iodization(USI)on the incidence of hyperthyroidism.Methods To investigate 37 619people from three different areas.(A:non iodine deficiency area.lodine is supplied early and the iodine concentration in salt increases rapidly before and after USI.B:severe iodine lack area,The iodine concentration doesn't change more obviously before and after USI.C:iodine deficiency area.The iodine supply time is nearly the same as the time of USI.So the concentration of iodine is up to relatively high suddenly).The thyroid function,thyroid autoimmune antibody,B-ultrasonic examination and urine iodine level were detected in 117 cases.Results The total incidence of hyperthyoidism increases singificantly from 4.53 per100 000 person s-yesr(95%Cl:1.6～11.7) to 24.53 per 100 000 persons-year (95%Cl:6.2～36.8).The relative risk of iodine supply to hyperthyroidism incidence is also high.Conclusions The earlier iodine supply,the earier the occurrence of hyperthyroidism.The inicdence of hyperthyroidism goes up consistent with the iodine concetration incerease.