~1H-NMR及计算机模拟法对鬼臼脂素脱水过程的研究(英文)

Study of the dehydration process of podophyllotoxin by using ~1H-NMR and computer simulation

鬼臼脂素脱水只能得到 β 不饱和苦鬼臼脂素 ,但却经过不稳定中间体α 不饱和鬼臼脂素。本文采用1H NMR和常用计算机软件对这一过程进行了跟踪 ,证明鬼臼脂素脱水确实经历了α 不饱和鬼臼脂素的形成。同时说明采用计算机模拟可有效地用于核磁共振谱的解析。

It is assumed that 'α-apopodophyllotoxin' was formed in the process of dehydration of podophyllotoxin.However,this process was not confirmed.Here we reported that we studied the process by using the 1H-NMR and computer simulation.