猪解剖生理学特点对猪原位肝移植的影响

Effect of anatomical and physiological features on orthotopic liver transplantation in pigs

目的 探讨猪原位肝移植模型的建立。 方法 根据猪的解剖生理学特点 ,采用体外静脉转流技术进行猪原位肝移植 (OLT)。 结果 16只OLT术后存活 14只 ,手术成功率 87.5 % ,术中血流动力学、血气电解质及体温均能维持在正常范围。 结论 猪原位肝移植过程中 ,采用体外静脉转流技术 ,以及根据猪的解剖生理学特点 。

Objective To study the setting up a model of orthotopic liver transplantation (OLT) in pigs. Methods In pigs, OLT were performed based on the porcine anatomical and physiological features, and the extracorporeal veno venous bypass was established during the anhepatice stage. Results Fourteen pigs(87.5%) of 16 OLT survived after the operation, and the haemodynamics?serum biochemical parameters and core temperature were maintained in the normal value during OLT. Conclusions Extracorporeal venovenous bypass and perfect surgical techniques based on the anatomical and physiological features are the key to successful OLT in pigs.