F波在糖尿病性周围神经病中的诊断价值

Diagnostic value of F wave in diabetic peripheral neuropathy

目的 探讨 F波在糖尿病性周围神经病 (DPN)中的诊断价值。方法 测定 10 6例糖尿病患者和 75名正常人的下肢 F波最短潜伏期、时限、波幅和面积 ,以及 M波波幅和面积。结果 (1)无周围神经病变的糖尿病患者 30例 ,F波时限增宽 8例 ,F波最短潜伏期延长 4例 ,F/ M波面积增大 2例。 (2 )有周围神经病变的糖尿病患者 76例 ,F波最短潜伏期均延长 ;F/ M波波幅和 F/ M波面积均增大 ;F波时限在轻型 DPN患者中增宽 ,在重型 DPN患者中未见明显异常。(3)正常人 F波最短潜伏期上限 (Y)与腿长 (X)的函数关系为 Y=12 .3+4 8.8X 2。结论 (1) F波可作为早期诊断 DPN的敏感指标 ,并可发现亚临床 DPN。(2 )在 DPN患者中 ,远端神经节段尚未发生病变时 ,即可出现近端神经节段病变 ,提示血管因素在 DPN发病机制中的作用。

Objective To investigate the diagnostic value of F wave in diabetic peripheral neuropathy (DPN).Methods F and M wave parameters were measured in 106 patients with diabetes mellitus and 75 normal persons, including the minimum latency, duration, amplitude and area of F wave, and the amplitude and the area of M wave.Results (1) In the 30 patients with diabetes mellitus without peripheral neuropathy, there were 8 cases with prolonged the duration of F wave, 4 cases with prolonged the minimum latency of F wave, 2 cases with increased in the ratio of the area of F/M wave. (2) The minimum latency prolonged of F wave, the ratio of the amplitude of F/M wave and the ratio of the area of F/M wave significantly increased in the 76 patients with DPN, the duration of F wave prolonged in the mild DPN but no one revealed remarkable abnormal. (3) In the controls, the function of upper limit of the minimum latency of F wave (Y) and leg length (X) was Y=12.3+48.8X 2. Conclusion (1) F wave could be served as sensitive index to the early diagnosis of DPN, and might detect subclinical DPN. (2) The proximal nerve segment could be affected without the lesions of the distal nerve segment in patients with DPN, and it suggested that vascular factor plays an important role in the mechanism of DPN.