红景天复方和乙酰唑胺对在海拔5380米居住1年青年睡眠时血氧饱和度的影响

The regulative effect of Rholida and Acetazolamide on sleep blood oxygen saturation at high altitude

目的 :探讨居住海拔 50 0 0米以上地区人群睡眠血氧饱和度 (SaO2 )的变化以及复方红景天和乙酰唑胺的调节作用。方法 :对居住海拔 5380米 1年的 2 4名青年随机分为A组 (红景天组 )、B组 (乙酰唑胺组 )和C组 (红景天 +乙酰唑胺组 ) ,每组 8人 ,在服药前和服药 2 4天后分别进行睡眠SaO2 监测。结果 :服药后较服药前清醒时SaO2 (WSaO2 )最高睡眠监测过程中SaO2 最低 (LSaO2 )和平均SaO2(MSaO2 )均增高 ,氧减饱和度指数 (DI4)及SaO2 80 %的时间占总监测时间的百分比(SIT80 )均降低 ,差异非常显著 (P <0 0 1 )与A组比较 ,服药后B组和C组 ,SIT80 降低不如A组明显 ,差别有显著性意义 (P <0 0 5)。WSaO2 、LSaO2 、MSaO2 及DI4各组间比较均无统计学意义 (P >0 0 5) ,结论 :红景天复方和乙酰唑胺均能明显提高睡眠SaO2 ,在改善SIT80 方面乙酰唑胺有优于红景天复方的趋势 。

Objective:To study the regulative effect of Rholida and Acetazolamide on sleep blood oxygen saturation(SaO 2) at high altitude. Methods:The 24 youths are randomly divided into A (Rholida group),B(Acetazolamide group) and C group(Rholida+Acetazolamide)who have stayed at high altitude(5380m) for one year.To record their sleep SaO 2 before and after taking drugs for 24 days. Results:The waking SaO 2(WSaO 2) and the lowest SaO 2(LSaO 2) and the mean SaO 2(MSaO 2)were increased greatly after taking drugs for 24 days(P<0.01),and the number of oxygen desaturation≥4% per hour(DI 4) and the percentage of time spent on SaO 2 below 80%(SIT 80 ) were decreased(P<0.01),it compared with Rholida group,B and C group's SIT 80 were increased(P<0.05) Conclusion:Both Rholida and Acetazolamide could improve the sleep SaO 2 at high altitude,and Acetazolamide has an advantage over Rholida in regulating SIT 80 ,but there is no cooperation between Rholida and Acetazolamide.