雷公藤多甙在儿童皮肌炎治疗中的地位探讨

On the total glycoside of tripterygium wilfordii hook F in the place of the treatment of juvenile dermatomyositis

目的 提高儿童皮肌炎的诊断、治疗水平。方法 对本院 1991～ 2 0 0 0年 10年间住院儿童皮肌炎进行分析总结。结果 6例儿童皮肌炎男女比例 1∶5 ,发病年龄 1 5～ 10岁 ,平均 5 38岁。晚期伴发广泛皮下钙沉积病例和诊断延误、激素用量不足有关。雷公藤多甙联合小剂量MTX脉冲疗法及小剂量激素 ,使钙沉积消除。结论 早期诊断、足量用药是争取儿童皮肌炎良好预后的关键。雷公藤多甙可能属本病的控制疾病治疗药。

Objective To improve the threshold of the diagnosis and therapeutic effect in juvenile dermatomyositis.Methods Data of hospitalized juvenile dermatomyositis patients during 1991～2000 were collected and analyzed.Results Six cases of juvenile dermatomyositis were included.Among them 1 was male and 5 female.Age at onset was 1.5～10 years 5.8 years on average.The cases at later stage with widespread calcinosis in soft tissue might be due to delay in diagnosis and improper treatment,which was successfully treated with total glycoside of tripterygium wilfordii hook F.Conclusion Early diagnosis and effective treatment was important for the good outcome of juvenile dermatomyositis.The Chinese medicine-total glycoside of triptergium wilfordii hook F can be the therapy for juvenile dermatomyositis.