载脂蛋白E基因多态性与脑梗死的关系

The Relation of Apolipoprotien E Gene Polymorphism Exist in Cerebral Infaction

目的:探讨载脂蛋白E(apo E)外显子4基因多态性与湖北汉族人脑梗死的关系。方法:分别采用聚合酶涟反应(PCR)结合限制性片段长度多态性方法检测apo E基因多态性。结果:脑梗死apo E外显子4基因多态性与正常对照组相比差异有显著性(P<0.01)。结论:apo E外显子4基因可能是汉族人脑梗死的遗传危险因素。

Objective: To explore the relation of apolipoprotien E extron 4 gene polymorphism exist in cerebral infaction of the Han people in Hubei province. Methods: The gene polymorphism were measured by polymerase chain reaction(PCR) and restriction fragment length polymorphisms(RFLP) assay. Results: The extron 4 gene polymorphism of apolipoprotien E in patient with cerebral infaction was increased significantly than normal group(P<0.01). Conclusion: Apolipoprotien E extron 4 gene may be a hereditary rick factor for patient with cerebral infaction of the Han people.