摘要
目的 :建立一种脑复康 (乙酰胺吡咯烷酮 )注射液的含量测定方法 ,以考察上市药品脑复康注射液的质量。方法 :采用高效液相色谱法[1,2 ] ,用ZORBAXSB -C18柱 ,以甲醇 -水 (2 5∶75 )为流动相 ,在波长 2 15nm处进行检测。结果 :乙酰胺吡咯烷酮在 10 0 15 5～ 5 0 0 775 μg·ml-1浓度范围内 ,线性关系良好 ,r=0 9998(n =6 ) ,平均回收率 10 1 12 % ,RSD =0 93% (n =5 )。结论 :本法适用于脑复康注射液的成品检验。
An HPLC method is developed for the determination of piracetam injection. ZORBAX SB-C18 column is used with a mobile phase of methanol-water (25∶75) and detection at wave-length 215nm. The calibration curve for piracetam was linear within the concentration range of 100 2～500 8ug·ml -1 (r=0 9998,n=6). The average recovery is 101 1% and RSD is 0 93%. The method can be used to determine the finished product of piracetam injection.
出处
《中国药事》
CAS
2002年第1期40-41,共2页
Chinese Pharmaceutical Affairs
