不同应激方式对大鼠血清一氧化氮合酶活性影响的差异性

Activity Difference of Nitric Oxide Synthase (NOS) in Serum of Rats under Different Stresses

目的 :研究不同应激方式对大鼠血清一氧化氮合酶 (NOS)活性影响的差异。方法 :采用强迫游泳和心理社会应激建立应激动物模型 ,于应激后 2小时测定两组血清NOS活性。结果 :强迫游泳应激后 ,NOS活性高于正常大鼠 (P <0 0 1) ;心理社会应激后 ,NOS活性显著降低 (P <0 0 5 )。结论 :不同的应激方式对NOS活性影响不一致 ,强迫游泳可能具有更多躯体方面的效应。

Objective: To study NOS activities in serum of rats under different stresses. Methods: Two models of stress were made in rats, one is the conventional forced swimming model (including 12 rats), and the other is a social defeated paradigm (including 12 rats). The activities of NOS of rats under each model and of one control group (10 rats) were measured. Results: Compared with control, the NOS activity under social defeated paradigm was lower (15.36±1.74/17.11±1.67 U/ml, t=2.32, P<0.05), while that under forced swimming was higher (18.90±1.24/17.11±1.67 U/ml, t=3.16, P<0.01). Conclusion: Forced swimming has more physical effect than social defeated paradigm in rats reflected by NOS activity in serum.