2型糖尿病血清超氧化物歧化酶及一氧化氮测定的临床意义

The Significance of Determiniry SOD and NO in Type 2 Diabetes

目的 探讨 2型糖尿病与超氧化物歧化酶 (SOD)及一氧化氮 (NO)的关系。方法 采用对照研究测定 89例 2型糖尿病病人和 112例正常对照组空腹后超氧化物歧化酶 (SOD)和一氧化氮 (NO)。结果 2型糖尿病患者组的血清SOD 86 7± 9 6(NU/ml) ,NO 79 3± 2 4 5 (NU /ml) ,正常对照组SOD 112± 11 69NU/ml) ,NO 62± 19 69(NU/ml) ,两组比较 ,P值均 <0 0 5。结论 2型糖尿病患者组血清SOD明显低于对照组 ,而NO含量明显高于对照组。 2型糖尿病患者NO含量升高可能与微血管病理变化有关 ,而SOD活性下降 ,加上高血糖状态造成糖尿病人各组织损伤 ,成为糖尿病各种并发症的重要基础。临床检测SOD或NO有助于了解 2型糖尿病病理生理变化情况 ,从而辅助治疗 。

Objective To approach the clinical significance of determining SOD and NO in type2 diabetes.Methods The activity of SOD and concentration of NO in sera in 89 cases with type2 deabetes and 112 persons in control group were determined.Results The activity of SOD and concertration of NO in group of type diabetes were 86 7±9 6(NU/ml),NO 79 3±24 5(NU/ml),respectively.The levels in control group were 112±11 69(NU/ml),NO 62±19 69(NU/ml),respectively( P <0 05).Conclusions The level of SOD in group of type2 diabetes is significantly higher than that in control group,however the level of NO in the two groups is reverse.