白芍总甙对豚鼠结肠平滑肌M受体作用的研究

The Effect of TGP on M Receptor of Colon Smooth Muscle in Guinea Pig

目的 :探讨白芍总甙对离体豚鼠结肠平滑肌的作用方式及结肠平滑肌M受体在调节结肠运动中的作用。方法 :制备豚鼠结肠纵肌和横肌肌条 ,观察不同剂量白芍总甙及工具药对离体结肠肌收缩活性的效应。结果 :白芍总甙使豚鼠结肠离体平滑肌收缩积分和时间显著性增加。且收缩效应的改变具有剂量依赖性。白芍总甙的这种作用能被阿托品抑制。结论 :白芍总甙可通过延长结肠收缩时间 ,增强结肠收缩幅度而调节结肠运动 ,结肠平滑肌M受体是白芍总甙作用途径之一。

Objective:To explore the effect of Total Glucosides of Paeony (TGP) on colon smooth muscle of Guinea pig and the regulative function of M receptor on colon motility in vitro. Methods:the transverse and longitudinal contraction role of smooth colon muscle strips at the different dosage of TGP and other medicine was separately observed. Results:TGP can make obvious traverse and longitudinal contraction. The effect of TGP can be reversed by atropine. Conclusion:TGP may regulate the motility of colon of Guinea pig through lengthening the time of contraction and M receptor may be one of the passages of TGP.