糖尿病患者骨质疏松相关因素及其机理的分析(附78例报告)

The Study of the Relation Factors and Mechanism of Osteooporosis with Diabetes Mellitus

目的 :研究糖尿病 (DM)患者骨密度的变化 ,了解DM患者是否易合并骨质疏松及其与相关因素之间的关系 ,并进一步探讨其骨质疏松的发病机理。方法 :采用以色列螺旋电子计算机断层扫描 (CT TWIN) ,测定 78例DM患者及对照组第 3腰椎 (L3)骨矿含量 (BMD) ,分析其年龄、性别、病程、空腹血糖 (FBG)、糖化血红蛋白 (HBA1C)、体重指数 (BMI)等之间的关系。统计学方法采用SAS和SPSSFORWINDOWS95统计软件分析处理。结果 :78例DM患者中 ,骨量下降及骨质疏松者 5 3例 ,占6 8% ;DM患者L3骨矿含量明显低于对照组。结论 :DM患者较易发生骨质疏松 ,其发生率与病程、年龄及HBA1C呈负相关 ,与FBG、BMI相关性不明显。老年女性DM患者BMD比男性下降更为明显 ,考虑与绝经后卵巢功能丧失有关。

Objective:To study the relationship between osteoprorosis and diabetes mellitus and discuss the mechanism of osteoporosis. Methods:The bone mineral density (BMD) of L3 of 78 subjects with Diabetes Mellitus (DM) and the controls were measured by the CT TWIN, and the relation among BMD, age sex, course of disease, FBG, HBA1C and BMI of both groups were analyzed. The software SAS and SPSS were used. Results:In 78 patients with diabetes mellitus, there were 53 cases of ostsoporosis whose BMD were significantly reduced. Compared with the controls, the BMD of L3 in the patients with diabetes mellitus were significantly decreased. Conclusion:The patients with diabetes mellitus were subject to osteoporosis and there was native relation with the course of the disease, age and HBA1C, but no relation with FBG, BMI; Compared with old man, the BMD of old woman with diabetes mellitus were significantly decreased. It connected with the deprivation of ovary function after climacterium.