幽门螺杆菌感染致胃粘液细胞膜通透性增高

The change of cell membrane permeability of mucous cells after Helicobacter pylori infection

目的 探讨 Hp感染后胃粘液细胞细胞膜通透性的改变 ,并探讨其临床意义。方法 采用常规 HE、 W- S染色、电镜细胞化学技术观察胃粘液细胞膜通透性 (D/L)的改变 ,并探讨 D/L与 Hp数量、 PMN浸润间的关系。结果 Hp感染后部分粘液细胞细胞膜的通透性 (D/L)增大 ,且 D/L值与 Hp的数量、PMN浸润程度均呈正相关 (P<0 .0 1 )。结论 Hp感染后胃粘膜屏障确有减弱或局部破坏 ,这可能是

Objective:To study the change of membrane permeability of some mucous cells after Helicobacter pylori(Hp)infection.Methods:Histopathologic techniques such as HE,W S staining,and electron microscopic cytochemistry technique were used to study the changes of gastric mucosa,and to evaluate the relationship between the number of Hp,PMN and the permeability of mucous cells(D/L).Results:Tannic acid staining showed cell membrane permeability of some mucous cells increased,the ratio of D/L correlated with the number of both Hp and PMN(P<0 01).Conclusion:The damage of gastric mucosal barrier after Hp infection is one of the important pathogenectity of Hp related diseases.