老年2型糖尿病微量白蛋白尿与胰岛素抵抗的关系探讨

Study of the relationship between microalbuminria in elder patient with type 2 diabetes mellitus and insulin resistance

目的 探讨老年 2型糖尿病微量白蛋白尿与血压、体重指数、高胰岛素血症以及胰岛素抵抗的关系。方法 按 WHO标准确诊的 2型糖尿病 57例全部在入院第一周内测定 2 4小时尿白蛋白排泄率 (2 4小时 UAE)。同时测血压以及血 BUN、CR、FBS、血浆空腹胰岛素 ,计算体重指数和胰岛素敏感性指数。结果 老年 2型糖尿病伴有早期糖尿病肾病的患者平均收缩压、体重指数及空腹血浆胰岛素均有显著增高 ,而胰岛素敏感性指数就有所下降。结论 为了防止老年人糖尿病慢性并发症的发生和发展 ,应尽早防治胰岛素抵抗 ,控制血压 ,合理控制饮食和运动 ,可提高胰岛素敏感性及反应性 。

Objective:To evaluate the relationship between microalbuminria and patients blood pressure,body mass index,hyperinsulinemia and insulin resistance.Methods:57cases with type 2 diabetes mellitus were checked 24 hours urinary albumin excretion(24h URE) in first week and the patients BP,Bun,Cr,FBG,and FIns were measured too.Taking count for BMI and ISI Results:Patients with early diabetic nephropathy shows statistical increasing in average SBP,BMI,FIns and decreasing of the ISI than control group.Conclusion:For prevent the occurrence and development of diabetes chronic complication,Insulin resistance should be treated in early.Controlling BP and restricting caloric intake be useful for enhancing.Insulin sensitivity and responsibility and decreasing the morbidity and mortality of diabetic nephropathy and cardiopathy in elderly.