运用羟基喜树碱与5-FU治疗恶性胸腔积液的对照观察

Control observation on HCPT and 5-FU therapy for malign pleural effusion

目的 :探讨羟基喜树碱 (HCPT)治疗恶性胸腔积液的疗效。方法 :5 7例恶性胸腔积液病人分为两组。 2 9例接受羟基喜树碱 (HCPT)治疗 ,2 8例接受 5 -FU治疗。结果 :羟基喜树碱 (HCPT)组完全控制率 2 7.6 % ,部分控制率 5 5 .2 % ,总有效率 82 .8 %。而运用 5 -FU组分别为 17.9% ,2 8.5 % ,4 6 .4 %。结论 :羟基喜树碱 (HCPT)疗效明显优于 5 -FU(p <0 0 1)。副作用低于5 -FU。

Objective: To evaluate therapeutical effect of HCPT on malign pleural effusion. Methods: 57 patients with malign pleural effusion were divided into two groups at random. The first group(29 cases)were treated with HCPT.The second group(28 cases) with 5-FU.Results: HCPT treatment group had a completel control rate 27.6%,partial control rate 55.2%,the total effective rate was 82.8%; 5-FU treatment group 17.9%,28.5%,46.4% respectively. Conclusion: Therapeutic effect of HCPT is obviously better than that of 5-FU(P<0.01).And the side effect is milder.