摘要
目的 观察中药制剂赋肝能 (由植物鹅绒萎陵菜Potentillaanserinal.分离提取而得的主要活性成分 ,简称FGN) ,对小鼠实验性肝损伤的保护作用 ,评价赋肝能的退黄降酶作用效果。方法 采用化学毒物四氯化碳 (CCl4 ) ,α萘异硫氰酸酯 (ANIT)致小鼠肝脏损伤 ,测定其生化指标并观察病理组织学改变。结果 赋肝能 0 .16 5 ,0 .0 82 5g·kg-1均能显著降低CCl4 肝损伤所致的小鼠血清丙氨酸转氨酶 (ALT)升高 (P <0 .0 1)及ANTT肝损伤所致的小鼠血清总胆红素 (SB)升高 (P <0 .0 1) ;赋肝能 0 .0 412 5g·kg-1对上述指标没有影响。结论 上述结果表明 。
OBJECTIVE: To study the protective effects of Fuganneng (FGN) on experimental hepatic injury in mice, and evaluate its effects of rejected jaundice and reduced enzyme. METHODS: The model of hepatic injury was induced by CCl4 and ANIT. The biochemical indexes were determined and the histopathological changes were observed. RESULTS: FGN 0.165 and 0.0825 g·kg-1 significantly inhibited the rising of serum alanine transaminase (ALT) and the serum bilirubin (SB) induced by CCl4 and ANIT respectively. (P -1 had no effects on the biochemical indexes mentioned above. CONCLUSION: FGN had significant protective effects on experimental hepatic injury in mice.
出处
《中国药学杂志》
EI
CAS
CSCD
北大核心
2001年第7期448-450,共3页
Chinese Pharmaceutical Journal
基金
"九五"国家新药基金课题 (96-90 1-0 5 -160 )
