恩氟烷中微量杂质的定性分析

Qualitative analysis of trace impurities in enflurane

目的 对恩氟烷中微量杂质进行定性。方法 采用气相色谱 质谱联用法。结果 1号杂质可能为CCl2 FCF2 O CClF2 ,2号杂质可能为CHClFCF2 O CClF2 ,3号杂质可能为CCl2 FCF2 O CHF2 ,4号杂质可能为CCl2 FCF2 O CHClF和CClF2 CF2 O CHF2 的混合物 ,5号杂质可能为CHF2 CClF O CHF2 ,6号杂质可能为CHF2 CClF O CHCl2 或CClF2 CHF O CHCl2 。结论 通过跟踪检测寻找到了杂质产生的原因 。

OBJECTIVE: To identify the six impurties in anaesthetic enflurane. METHOD: GC/MS was used. RESULTS: The impurities were found as (1)CCl2FCF2-O-CClF2, (2)CHClFCF2-O-CClF2, (3)CCl2FCF2-O-CHF2, (4)the mixture of CHCl2FCF2-O-CHClF and CClF2CF2-O-CHF2, (5)CHF2CClF-O-CHF2, (6)CHF2CClF-O-CHCl2 or CClF2CHF-O-CHCl2. CONCLUSION: It was explored where the six trace impurities were developed in the production of enflurane.