乳腺错构瘤8例分析

A study on mammary hamartomas (8 cases)

目的 总结乳腺错构瘤病理特点并分析其临床、组织学及免疫组织化学 (免疫组化 )特征。方法 组织标本经 10 %福尔马林固定 ,常规石蜡切片 ,HE染色。用SP法进行免疫组织化学标记。结果 8例错构瘤组织学镜下境界清楚 ,由数量不等的纤维、脂肪、乳腺小叶及导管成分组成。上皮成分无非典型性 ,出现不同程度雌激素受体 (ER)阳性。结论 乳腺错构瘤为良性病变 ,组织学上与其它乳腺肿瘤不同 ,与雌激素水平有关 ,确诊需临床。

Objective To study the clinical, histological and immunohistochemical features of breast hamartomas. Methods The specimens were fixed in 10% formalin and embedded in paraffin. The sections were stained with hematoxylin and eosin for histological diagnosis. SP technique was used in the immunohistochemical study.Results We have 8 cases of breast hamartomas with well defined borders microscopically, histologically composed of ducts, lobules, fibrous stroma, adipose tissue. None of the epithelial elements showed any evidence of atypia. Immunohistochemical analysis showed that there was a variable number of epithelial cells showing a nuclear staining for estrogen receptor(ER) in all cases.Conclution Mammary hamartomas are benign tumor like lesions, histologically dissimillar from other breast tumors. It is affected by hormonal factors. The diagnosis is achieved by combining clinical, radiological and pathologic results.