恶性肿瘤患者化疗及附加免疫治疗后淋巴细胞亚群的变化

Effects of chemoimmunotherapy on lymphocyte subsets in patients with malignant tumors

目的 了解恶性肿瘤患者化疗和附加免疫治疗前后淋巴细胞亚群的变化及其临床意义。方法 利用流式细胞仪测定 5 1例化疗前后和 2 6例附加免疫治疗前后的淋巴细胞亚群及其活性。结果 化疗后 1周患者CD3+ 、CD4 + 及NK细胞较化疗前明显降低 (P <0 0 5 ) ,CD8+ 、CD19+ 细胞无明显变化 (P >0 0 5 )。附加免疫治疗组治疗后 1周CD8+ 及NK细胞较化疗前明显升高 (P <0 0 5及P <0 0 1) ,CD4 + 细胞、CD4 + /CD8+ 比值降低 (P <0 0 1)。结论 化疗对恶性肿瘤患者细胞免疫功能有明显抑制作用。附加免疫治疗对恶性肿瘤患者细胞免疫功能有明显改善作用。生物反应调节剂能增强化疗患者的细胞免疫功能 。

Objective To study lymphocyte subsets changes in patients with malignant tumors during chemoimmunotherapy and the clinical significance. Metheds Fifty one cases were treated with chemotherapy and twenty six cases with chemoimmunotherapy. Lymphocyte subsets were determined by flow cytometry. Results Chemotherapy significantly decreased CD 3 +, CD 4 + and NK cells ( P <0 05), while CD 8 + and CD 19 + cells remained unchanged ( P >0 05). Chemoimmunotherapy elevated CD 8 + and NK cells ( P <0 05 and P <0 01 respectively), and decreased CD 4 + cells and the ratio of CD 4 +/CD 8 +(all P <0 01). Conclusion Chemotherapy suppresses the cell immune, and biological response modifiers improve the cell immunological function of patients with malignant tumors.