CD_(43)CD_(20)及总IgE在鼻息肉组织中表达的研究

Roles of CD_(43), CD_(20) and local IgE in the pathogenesis of nasal polyps

目的 探讨CD4 3 、CD2 0 及总IgE在鼻息肉组织中的表达 ,分析其在鼻息肉发病中的作用。方法 采用免疫组化SP法及HE染色对 2 5例鼻息肉和 2 0例中鼻甲粘膜进行研究。结果 鼻息肉组织中CD+ 43 细胞和CD+ 2 0 细胞、浆细胞数显著多于中鼻甲粘膜组织 (P <0 0 1) ,总IgE阳性表达率为44 %,显著高于中鼻甲粘膜组织的 10 %(P <0 0 5 )。结论 鼻息肉中存在活跃的细胞免疫和体液免疫 ,鼻粘膜局部变态反应可能参与鼻息肉的发病。

Objective To estimate the roles of CD 43 , CD 20 and total IgE in the pathogenesis of nasal polyps. Method Twenty-six cases of nasal polyps and 20 cases of mucosa of middle turbinates were used in present study. Results The number of CD + 43 cells,CD + 20 cells and plasma cells in nasal polyps were significantly more than that in middle turbinates (P<0.01). The positive rate of local IgE + cells in nasal polyps was significantly higher than in middle turbinate (P<0.01). Conclusion There were active cellular immunity and humoral immunity in nasal polyps. Local allergy may play a role in the pathogenesis of nasal polyps.