褪黑素鼻粘膜吸收规律的研究

Study on melatonin nasal absorption

目的 :研究褪黑素鼻粘膜吸收规律。方法 :观察褪黑素在大鼠鼻腔洗出液中的稳定性 ,在此基础上 ,以大鼠在体鼻循环为实验模型 ,研究褪黑素鼻粘膜吸收规律。 结果 :褪黑素在鼻粘膜洗出液中稳定性良好 ,在鼻粘膜吸收符合一级动力学方程 ,褪黑素鼻粘膜吸收常数不随药物浓度发生变化。结论 :褪黑素在鼻粘膜的吸收机制为被动扩散 ,其在鼻粘膜平均吸收速率常数为 1.0 5 4× 10 -2

Objective:To research the rule of melatonin nasal absorption.Methods: The stability of melatonin in rat nasal wash was studied, after that the in situ rat nasal recirculation methods were used as experimental animal model to study the rule of melatonin nasal absorption.Results:Melatonin was stable in rat nasal wash, its absorption in nasal cavity accorded with first order kinetic equation. The absorption rate constants did not vary with melatonin concentrations.Conclusion:The mechanism of melatonin nasal absorption is passive diffusion, the average absorption rate constant is 1.054×10 -2 min -1 .