脑白质疏松的病理与影像学关系的研究

Study on relations between pathological and imaging changes of leukoaraiosis

目的 研究脑白质疏松确切的病理变化及其与影像学 (CT/MRI)的关系。方法 将 10年来我科收治的 6 3例影像学表现为脑白质疏松的患者的临床及影像学资料进行总结 ,其中 10例死后进行了病理检查。结果 脑室周围深部白质、半卵圆中心、放射冠部位的病理学表现为 :①髓鞘结构紊乱、体积变小、数量减少。②轴索变性、萎缩和脱失。③白质内明显的小血管硬化和胶质细胞增生。④多发性腔隙性梗死灶。结论 病理证实的脱髓鞘改变、CT显示的脑室周围低密度性改变、MRI的T2

Objective To study the exact pathological change of leukoaraiosis(LA) and the relations between pathological and imaging changes of leukoraiosis.Methods We summed up the clinical and imaging materials of 63 LA inpatients from 1990 to 2000 and anatomized 10 cases of them.Results The pathological change at white matter around the brain ventricles at this site manifested:①As to the myclin sheath,the structure of was mussy,the volume lessened,the quantity decreased;②The axon degenerated,shrivel and vanished;③There were obvious sclerosis of small vessel and collagenous hyperplasia in white matter;④There were multiple lacunae infarct lesions.Conclusion The results suggests that the changes of demyelinization in white matter around the brain ventricles verified by pathology examination,the low density change around the brain ventricles on CT,the high signal change around the brain ventricles on weighted image of MRI,these three changes are at the same site.