溴隐亭治疗垂体催乳素瘤和特发性高催乳素血症的探讨

Application of bromocriptine in the treatment of pituitary gland proiactin tumor and hyperprolactinemia.

目的 探讨溴隐亭在治疗垂体催乳素瘤和特发性高催乳素血症过程中的用药剂量、用药时间及妊娠期用药问题。方法 对 3 6例患者进行临床分析 ,比较治疗前后月经恢复情况、妊娠率、妊娠期用药时间、剂量及对胎儿的影响。结果 患者均停止泌乳 ,月经恢复率 10 0 .0 % ,妊娠率 85 .7% ,血催乳素 (PRL)降至正常 ,瘤体显著缩小。结论 垂体催乳素瘤和高催乳素血症的治疗应以溴隐亭为首选 ,药物剂量因人而异 ,可反复使用 ,副作用少 ,对胎儿较安全 ;在治疗垂体催乳素瘤时 ,前 3周要用足量 ,使血PRL迅速下降 ,无论是否妊娠均不能轻易停药 ,部分患者术后仍必须用药治疗。

Objective To investigate the dose, the course and cautions during pregnancy of bromocriptine in the treatment of pituitary gland proiactin tumor and hyperprolactinemia (HPRL).Methods The clinical manifestations of the 36 patients were analyzed.The status of menstruation was compared before and after treatment.The following parameters were observed:ratio of pregnancy, the hour of therapy during pregnancy, dose and the effect on fetus.Results All the patients ceased to excrete latex, the ratio of restoration of menstruation was 100.0%, and ratio of pregnancy 85.7%.PRL was decreased to a normal level and tumor shrank obviously.Conclusion Bromocriptine was the first choice in the treatment of pituitary gland prolactin tumor and HPRL.The dose of the medicine should be individualized.It has few side effects and can be used repeatedly.During the treatment of pituitary gland prolactin tumor, the dose should be adequacy to rapidly decrease the PRL.Pregnancy was not the contraindication for bromocriptine use.Partial patients should go on therapy after the operation.