卡维地洛对降压及血清Ⅲ型前胶原氨基端肽的影响

Effects of carvediol on blood pressure and levels of serum PⅢNP in patients with essential hypertension

目的 :观察卡维地洛对原发性高血压 (EH)患者的降压效果及对血清Ⅲ型前胶原氨基端肽 (PⅢNP)及去甲肾上腺素 (NE)、肾上腺素 (E)水平的影响。方法 :EH患者服用卡维地洛治疗 12周 ,观察治疗前后心率、血压及血清PⅢNP及血浆NE、E水平的变化。结果 :EH患者治疗前血压、心率、血清PⅢNP及血浆NE、E水平显著高于正常对照组。治疗 12周后血压、心率、血清PⅢNP及血浆NE、E水平较前显著降低。治疗前后血压与血清PⅢNP水平间无明显相关性。结论 :卡维地洛可以有效控制血压、降低血清PⅢNP及血浆NE、E水平且副作用少 。

Objective:To observe the effects of carvedilol on blood pressure and levels of serum PⅢNP and plasma NE, E.Method:Thirty patients with mild to moderate essential hypertension (EH) and 15 healthy individuals as control group were enrolled. EH patients were given carvediol tablets, 10 mg once daily and the maximum dose stepped up to 40 mg once daily if necessary. The blood pressure, heart rate and levels of serum PⅢNP and plasma NE, E of EH patients were investigated before and after treatment.Result:The blood pressure, heart rate, levels of serum PⅢNP and plasma NE, E of EH patients were significantly higher compared with those of healthy control group and decreased significantly after 12 weeks treatment with carvedilol. There was no significant correlation between blood pressure and the level of serum PⅢNP in EH patients before and after treatment.Conclusion:Carvedilol tablets, 10～40 mg once daily can lower blood pressure and levels of serum PⅢNP and plasma NE, E effectively in EH patients.