胃粘膜组织中bcl-2、bax蛋白表达与胃癌的关系

The Relationship between Expression of bcl-2、Bax and Gastric Cancer

目的 :探讨 bcl- 2、bax表达在胃癌多基因、多阶段发展过程中可能的作用机制。方法 :采用免疫组化法对 79例临床标本 (慢性浅表性胃炎 30例、萎缩性胃炎 14例、胃炎伴异型增生 2 0例、胃癌 15 )进行了 bcl- 2、bax蛋白表达的检测。结果 :在慢性浅表性胃炎组中无 bcl- 2表达 ,异型增生组阳性表达率 5 % ,胃癌组为 2 0 % ,阳性表达率呈逐渐增加趋势 ;bax蛋白阳性表达率在慢性浅表性胃炎组为83.3% ,萎缩性胃炎组为 64.3% ,异型增生组为 60 % ,胃癌组为 4 6.7% ,阳性表达率呈逐渐减少趋势。结论 :本研究结果提示在胃癌的多阶段发展过程中可能存在促凋亡基因 bax的表达逐渐受抑及抑凋亡基因的表达逐渐增加 。

Objectives: To investigate the relationship between the expression of gene of bcl 2?bax and development of gastric cancer.Methods:79 patients underwent endoscopy ,samples were taken.ABC immunohistochemical staining was used to detect the expression of bcl 2?bax proteins.Results:There was significant difference in the positive rate of bcl 2 expression in group of chronic superficial gastritis,dysplasia and gastric cancer.(P<0.05).There was prevalence of the positive rate of bcl 2 expression was gradually increasing.The positive rate of bax expression was significantly higher in chronic superficial gastritis than that in gastric cancer.(P<0.01).There was significant difference in the positive rate of bax expression between the group of chronic superficial gastritis and group of dysplasia(P<0.05).Samely,there was prevalence that the positive rate of bax expression was gradually decreasing.Conclusions:There was disorder in apotosos during development of gastric cancer.