珍菊降压片与其他一线降压药治疗原发性高血压临床研究

Evaluation of Zhenjujiangya Tablet and Other Depressors of First Choice in Treatment of Essential Hypertension

目的 :比较珍菊降压片与其他一线降压药小剂量单用及联用对原发性高血压的有效治疗率。方法 :原发性高血压46 6例分别给予珍菊降压片、CCB(非洛地平或硝苯地平 )、ACEI(苯那普利或卡托普利 )、美托洛尔或吲达帕胺治疗 ,未达治疗目标者二药、三药乃至四药合用 ,直至达到目标血压 (<140 / 90mmHg)为止。 结果 :珍菊降压片单用的有效治疗率72 .8% ,高于其他 4类一线降压药 (4 6 .2 %～ 5 4.0 % ) (P <0 .0 5 ) ;与ACEI与CCB合用可进一步提高有效控制率 (92 .9% 97.1% ) ,且耐受性良好。结论 :珍菊降压片价廉效好 。

Objective:To study the clinical effect of Zhenjujiangya Tablet and other depressor of first choice alone in small dosage or combination in treatment of essential hypertension. Methods: 466 patients with essential hypertension were treated with Zhenjujiangya Tablet, CCB(Felodipine or Nifedipine), ACEI(Benazepril or Captopril), Metoprolol or Indapamide, respectively. If the blood pressure of patients didn't go down to the target one(<140/90mmHg) after treatment they would be treated again with two drug, three drug till four drug combination. Results: The effective rate of Zhenjujiangya Tablet alone was 72.8%, which was higher than that of other depressor of first choice(46.2%～54.0%)( P <0.05). The treatment with Zhenjujiangya Tablet associated with ACEI and CCB could raise further the effective control rate(92.9%～97.1%), and showed good tolerance. Conclusion: Zhenjujiangya Tablet is cheap and effective. It can be also used to be depressor of first choice.