摘要
目的 :按照新药审批指南的要求 ,对热感灵治疗外感热证进行药效学研究。方法 :热感灵给动物灌服后 ,分别观察其对伤寒Vi多糖疫苗所致家兔发热模型 ,2 ,4 二硝基苯酚所致大鼠发热模型的解热作用 ,对大鼠棉球肉芽肿模型的抗炎作用 ,对 2 ,4 二硝基氯苯所致小鼠迟发型过敏反应的抗过敏作用。液体试管法观察热感灵对 8种与呼吸道感染有关的病原菌和条件致病菌的体外抑菌作用。结果 :热感灵能显著抑制疫苗和化学致热剂所致动物体温的升高 ,抑制大鼠棉球肉芽肿和小鼠迟发型过敏反应 ,对 8种病菌也有显著抑制作用。结论 :热感灵具有良好的解热、抗炎。
Objective: To study the pharmacodynamic effect of Reganling Oral Liquid(RGL) in treating wind heat epidemic syndrome. Methods: After RGL was administered ig to experiment animals, we observed its antifebrile effect by using pathologic hectic rabbit caused by typhoid bacterin and pathologic hectic rat caused by injection of 2,4 dinitro phenol, anti inflammation effect by weighing the tampon acestoma in rat, anti anaphylaxis effect by using delay anaphylactoid mice caused by injection of 2,4 dinitrochloro benzene. The Liquid Tube Observing Method was used to investigate the bacteriostatic activity of RGL on eight kinds of germina in vitro . Results: RGL could evidently inhibit the raising of animal heat caused by bacterin and chemical, and also could markedly restrain the weight of tampon acestoma in rat and delay anaphylactoid in mice. RGL also had remarkably bacteriostatic activity on eight kinds of germina in vitro which mainly caused wind heat epidemic syndrome. Conclusion: RGL had the evident effects of antifebrile, anti inflammation, anti anaphylaxis and bacteriostatic activity in vitro .
出处
《中成药》
CAS
CSCD
北大核心
2001年第12期888-891,共4页
Chinese Traditional Patent Medicine
关键词
热感灵
外感热证
药理学
Reganling
Wind heat epidemic syndrome
pharmacodynamic study