红参中水溶性成分三七素的生理活性研究

Study on Water-soluble Components of Red Ginseng

目的 :从红参粉种分离三七素 ,并研究其新的生理活性。红参粉末中发现含有三七素 (β N oxalo L α ,βdiaminopropi onicacid)。方法 :应用离子交换葡聚糖凝胶色谱柱 (CM SephadexC 2 5 )和快速蛋白质液相色谱柱 (FPLCMonoQ)分离。结果 :三七素对豚鼠主动脉收缩作用的影响 ,在没有组织胺或肾上腺素存在的情况下 ,既无收缩作用也无松驰作用。它能增益组织胺诱导豚鼠主动脉的收缩 ,但对于肾上腺素却无此种作用。此外 ,三七素通过肾上腺素、ADP凝血酶和胶原均无诱导血小板聚集的作用。三七素对于血管紧张肽转移酶也无阻抑作用。结论

Objective:β N oxalo L α,β diaminopropionic acid were isolated from the powder of red ginseng. its physiological characteristics were studied. Method:This material is obtained by CM Sephadex C 25 and FPLC MonoQ. We have examined the effect of β N oxalo L α,β diaminopropionic acid on contraction of artery of guinea pig. Result:When histamin and adrenalin do not exist, there is neither contraction nor relaxation. It can strengthen induction of contraction of artery of guinea pig, but it has no such effect on adrenalin. Besides, it doesn't induce plaque coagulation through adrenalin, ADP blood coagulation enzyme and collagen. It doesn't suppress the transformation from tension peptide of blood vessel to enzyme.Conclusion:Hemostatic effect of β N oxalo L α,β dlaminopropinomie acid may caused by vesseles contraction through promoting Histamine.