糖皮质激素性青光眼视盘损害与用药时间的关系

The relationship between optic disc injury and duration administrating glucocorticoid in glucocorticoid induced glaucoma

目的 :观察糖皮质激素性青光眼视盘损害与用药时间的关系。方法 :对随访观察资料完整的糖皮质激素性青光眼 5 0例 98眼进行分析。结果 :青少年和男性患者较多 ,平均年龄 2 0 .3± 2 2 .2岁 ,男女之比为 3.2∶ 1。连续用药 6个月以上即可出现视盘病理性改变。视盘及视野损害的程度随用药时间的增加而增加。用药时间 1年以上和少于 1年者 ,C/ D≥ 0 .6者分虽为 80 .7%和 2 6 .7% (P<0 .0 0 5 ) ,视野损害者分别为 84.3%和 2 6 .7% (P<0 .0 0 5 )。双眼用药者双眼视盘及视野改变不一致者占 5 6 % 3%。结论 :该病多发生于男性青少年。视盘损害的程度与用药时间明显相关。双眼用药者 。

Objective: To investigate the relationship between the optic disc injury and the duration administrating glucocorticoid (GC) in the glucocorticoid induced glaucoma (GIC). Methods: 50 cases (98 eyes) with GIC were followed up and analyzed. Results: Juvenile and male patients are dominant, average age was 20.3±2.2 years old, the ratio between man and woman was 3.2:1. The pathologic changes in optic disc could be found when the GC was used over 6 months. The degrees of the optic disc injury and visual field injury got more serious with the increased time applying GC. In the patients who had been administrated GC for over one year or less one year, the percentages of C/D≥0.6 were 80.7% and 26.7% (P<0.005), and the visual field injuries were 84.3% and 26.7% (p<0.005). In the cases whose both eyes were administered with GC at the same time, the changes in the optic disc and visual field were inconsistent between both eyes in 56.3% of the patients. Conclusions: GIC is usually found in young man, and the degree of the optic disc injury is obviously related with the duration administrating GC. In at least 1/2 of the patients whose both eyes were administered with GC, the changes in the optic and visual field were inconsistent between both eyes.