老年原发性高血压患者纤溶活性和D-二聚体的变化及其意义

Changes of fibrinolytic activity and D-Dimer level in the primary hypertention of the elderly and their significance

目的了解纤溶活性和 D-二聚体变化在老年原发性高血压中的作用。方法采用 EL ISA法测定血、尿 D-二聚体 ,用发色底物法测定组织型纤溶酶原激活剂 ( t-PA)及纤溶酶原激活剂抑制剂 -1( PAI-1)活性。结果老年原发性高血压及老年高血压肾病组的 PAI-1,D-二聚体纤溶酶原明显高于正常对照组 ,t-PA纤溶酶活性水平低于正常对照组。结论纤溶活性和 D-二聚体在老年高血压、老年高血压肾病中具有重要作用 ,可作为老年高血压合并肾病早期诊断依据。

Objective To investigate the changes of plasma fibrinolytic activity and D dimer level in the primary hypertension of the elderly.Methods ELISA was applied to measure blood and urine D dimer.Chromophore substrate method was used to detect PL,Plg,t PA and PAI 1.Results The levels of PAI 1,D dimer and Plg were obviously higher in the elderly primary hypertension and hypertentive kidney disease than those in the control group,while t PA and PL activity were lower than in the control group.Conclusion The changes of PLA and D dimer play an important role in hypertension and hypertentive renal disease of the elderly,on which the early diagnosis can be based.