胸水P_(53)基因测序在肺癌诊断中价值的探讨

P_(53) gene sequencing of pleural effusions in lung cancer

目的 :评价胸水P53基因测序在肺癌诊断中的价值。方法 :对 46例肺癌合并胸腔积液患者的活检组织标本、胸水标本进行P53基因测序 ,并用 30例非癌性胸水标本作对照。结果 :在 46例肺癌合并胸腔积液患者中 ,活检组织P53基因突变率为41 30 % ,胸水P53基因突变率为 32 6 0 % (P >0 0 5 ) ,而非癌性胸水P53基因突变率仅为 3 33% (P <0 0 0 5 )。结论 :胸水P53基因测序对于肺癌的诊断 。

Objective:To evalute the diagnostic value of P 53 gene sequncing in lung cancer.Methods:The P 53 gene mutation of lung tissues and pleural effusions specimen in 46 patients with lung cancer accompanied pleural effusions was detected,constrasted with pleural effusions 30 patients with no cancer.Result:In 46 patients of lung cancer with pleural effusions,the P 53 gene mutation rates was 41 3%(19/46)in living specimen and 32 6%(15/46,P>0 05)in pleural effusions.In 30 patients with no cancer ,the P 53 gene mutation rates in pleura effusions was 3 33%(P<0 05).Conclusion:It suggested that P 53 gene sequencing in pleural effusion may be a help for dignosis of lung cancer and the diffrential dignosis of magligment pleural effusion.