高碘与高氟在实验性甲状腺肿和氟中毒发病中联合作用的研究

THE COMBINED ACTION OF IODINE AND FLUORINE IN EXPERIMENTAL IODINE—GOITER AND FIUOROSIS

用小鼠对碘、氟在甲状腺肿、氟中毒发病中的联合作用进行了研究。105只雄性昆明种小鼠随机分为五组,即对照组、高氟Ⅰ组、高氟Ⅱ组、高碘组和高碘高氟组。研究发现:高Ⅰ、高碘、高碘高组之甲状腺重量均大于对照组(P<0.01);高碘及高碘高组之甲状腺6小时吸碘率低于其它各组(P<0.01),符合一般规律,但高碘高组之甲状腺吸碘率高于高碘组;实验第90天,碘交互作用对鼠门齿斑釉发病影响有显著性。提示:水源性高碘、高及高碘高均可引起甲状腺肿;高碘抑制甲状腺对碘的摄取,而高具有刺激甲状腺摄碘之趋势;高碘可以延缓的致斑牙作用。

The combined action of iodine and fluorine in experimental iodine-goiter and fluorosis of mice was studied. 105 mice were divided into five groups:① control, ② excess fluorine one (EFI), ③ excess fluorine two (EF2), ④ excess iodine (EI), ⑤ excess iodine and excess fluorine (EI&EF). We found that the thyroid weights of EF1, EI and EI&EF were higher than those of control (p<0.01); the thyroid ^(131)iodine uptake rates at 6 hour of EI and EI&EF were lower than those of control, EF1 and EF2 (p<0.01); it is interesting that the ^(131)iodine uptake rate of EI&EF was higher than that of EI. On the 90 day, and besides fluorine, the interaction between iodine and fluorine was another cause to induce mice incisor fluorosis. It prompted that all of EI, EF, and EI&EF can cause goiter: excess iodine inhibits thyroid to uptake ^(131)iodine but excess fluorine stimulates thyroid to uptake ^(131)iodine; excess iodine may delay the fluorine action on dental fluorosis.