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聚合人血清白蛋白受体在乙肝病毒感染中临床意义的研究

STUDY ON THE CLINICAL SIGNIFICANCE OF RECEPTOR rFOR POLYMERIZID HUMAN SERUM ALBUMIN IN PATIENTS WITH HBV
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摘要 对191例各类HBV感染者检测了PHSA受体、HBVDNA、e系统以及其它HBV的血清学标志,其中28例做了肝穿活检,25例进行了1~10个月的追踪观察。结果表明:PHSA受体与HBVDNA密切相关,随着PHSA受体滴度的升高,HBVDNA的水平也相应增高。PHSA受体主要存在于HBeAg阳性血清中,但18例抗一HBe阳性者亦为PHSA受体阳性,并且7例为HBVDNA阳性。PHSA受体的平均几何滴度以慢性肝病为高(ASC、CPH和CAH),急肝较低(AVH)。9例PHSA受体阳性的急肝病人,其中4例在发病时,其PHSA受体滴度<2^(10),6个月后,肝功能恢复正常,PHSA受体转阴。而5例发病时PHSA受体滴度≥2^(10)的病人,除1例外,均转为CPH,并且PHSA受体未见转阴。 One hundred arid ninty-one patients suffering from various kinds of HBV were tested for PHSA-receptor, HBVDNA, e-system, and other markers of HBV in sera. The liver biopsy specimens from 28 cases of chr6nic HBV infection were examined. Some of the 191 cases were followed up for 6-10 months, and the results were as follows: PHSA-receptor was closely associated with HBVDNA. Along with the increasing tilers of PHSA-receptor, the level of HBVDNA rose. The PHSA-receptor were detected mainly in the sera containing HBeAg, but also found in the sera of 18 Anti-HBe positive cases, in whom seven were HBVDNA positive, the tilers of PHSA-receptors (GMT) in sera of patients with ASC, CPH, and CAH were higher than in those with AVH. 9 AVH cases were PHSA-recptor positive. Of those 9 patients, with PHSA-receptors of tilers less than 2^(10) at clinical onset, 4 became normal in SGPT and negative for PHSA-receptor in 6 months after onset. In five of the 9 cases, with PHSA-receptors more than 2^(10), turned to CPH, all 5 cases PHSA-receptor remained positive.
出处 《河北医学院学报》 1989年第2期74-78,共5页
关键词 PHSA 受体 HBV DNA 斑点杂交 乙型肝炎 PHSA-receptor HBVDNA Spot-hybridization
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