摘要
心室纤颤阈值(Ventricular Fibrillation Threshold,VFT)是目前抗心律失常药物药效评定方法之一。本文利用序贯性 R/T 刺激法测定 VFT,发现静脉注射人参总皂甙20mg/kg,可显著提高犬正常和急性缺血心脏的 VFT,同时可使右心室有效不应期延长,但不影响 QTC。
The effect of ginsenosides on the ventricular fibrillation threshold (VFT) in both normal and ischemic hearts of dogs were observed.The VFT was determined by sequential R/T pulsing.Ginsenosides (20mg/kg) increased significantly the VFT in both normal and acute ischemic hear- ts and hearts after having been treated by autonomic blockers,propra- nolol and atropine sulfate.We also found that ginsenosides prolonged t- he right ventricular effective refractory period (ERP).The results sug- gested that ginsenosides can exert a protective effect on ventricular fibrillation,especially in early acute myocardial infarction.
出处
《江西医学院学报》
1989年第1期4-8,共5页
Acta Academiae Medicinae Jiangxi
关键词
心室纤颤
人参总皂甙
心室纤颤阀值
抗心律失常药
心肌缺血
动物实验
ginseng
ponins/pharmacodynamics
ventricular fibrillation/physiopat hology
subliminal stimulation
propranolol/pharmacodynamics
atropine/pharmacodynamics
animals,laboratory
dogs
