淋巴细胞恶性疾病HTLV-Ⅰ抗原及抗体的测定分析

Detection and Analysis of HTLV-I Antibodies and Antigen in Patients with Lymphocyte Malignant Disease

本文以间接免疫萤光法测定96例淋巴细胞恶性患者血清中抗人T细胞白血病病毒Ⅰ型(HTLV—1)抗体。其中,80例急性淋巴细胞白血病;12例非何杰金氏淋巴瘤;4例慢性淋巴细胞白血病。发现一例成人抗HTLV—1抗体阳性,抗体滴度1:80,阳性率1.04％。並在培养细胞中检出HTLV—1抗原阳性细胞,前后两次阳性率分别为1.7～1.5％(P>0.05)。确诊病人已感染本病毒,提示HTLV—1已传入江西。认为测定HTLV—1抗原比抗体更重要,可用于早期确诊及游行病学调查。

Anti-adult T-cell leukemia virus (ATLV)/human T-cell leukemia virus type-1 (HTLV-Ⅰ) antibodies in 80 cases of adult lymphocytic leukemia(ALL), 12 of non-Hodgkins lymphoma,4 of chronic lymphocytic leukemia (CLL) were examined. Anti-HTLV-Ⅰ antibody was deteced in 1 case of adult T-cell malignant lymphoma (AT-ML)1.04%, titer of anti-HTLV-Ⅰ antibody being 1:80. Antigen of HTLV-Ⅰ was detected in AT-MA with anti-HTLV-Ⅰ antibody, with positive cell 1.7%-1.5%. The results suggest that the patient has been infected with HTLV-1. The detection of HTLV-Ⅰ antibody and antigen is useful to the early diagnosis and epidemiology of T-cell leukemia/lymphoma.