纳洛酮对大鼠急性冠脉闭塞早期心肌舒缩性的影响

The Effects of Naloxone on Myocardial Contractility and Relaxation during Early Stage of Acute Coronary Artery Occlusion in Rats

观察了阿片受体抗拮剂纳洛酮(naloxone)对大鼠左冠状动脉前降支(LAD)结扎后心肌舒缩性能变化的影响。LAD 结扎后4min,实验组经股静脉注射纳洛酮10mg/kg,对照组用生理盐水。结果:在 LAD 结扎后60min 内,实验组左室 dp/dt max、Vmax 和-dp/dt max均明显高于对照组(P<0.05),表明纳洛酮可抑制急性冠脉闭塞早期心肌收缩和舒张性能的降低,提示内源性阿片样肽可能参与急性心肌梗塞早期心肌舒缩性能降低的机制。

The effects of naloxone on myocardial contractility and relaxation after left anterior descending coro nary artery ligation in rats were ob- served.The dp/dt max,Vmax and-dp/dt max in the experimental group treated with naloxone(10 mg/kg,iv)were significantly higher than those in the control group(p<0.05)within 60 minutes after coronary ar- tery ligation.These results indecated that naloxone inhibited a decrease in myocardial contractility and relaxation during the early stage of acute coronary occlusion.It probably supports the notion that endogenous o- pioid peptides might be involved in the mechanism of the decrease in myocardial contractility and relaxation during acute myocardial infarc- tion.