测定血清及尿β_2微球蛋白评估健康老年人肾功能的价值

Evaluation of Renal Function of the Aged by Determination of Blood and Urine β_2-microglobulin

测定72例健康老年人(60～84岁)和65例健康青中年人(20～50岁)血清和尿β_2微球蛋白(β_2m),发现前者血清β_2m 浓度比后者明显增高(p<0.001);老年组≥70岁者尿液β_2m浓度也明显增高(p<0.05)。结果表明肾小球滤过率下降随年龄增长而降低,以后再出现肾小管功能减退。本试验较血清尿素氮、肌酐和内生肌酐清除率测定更为敏感。

The level of β_2-m in the blood and urine was determined in seventy two healthy old persons(60 to 84 years)and sixty five young-and middle- aged persons(20 to 50 years).The level of β_2 m in the blood of the for- mer was significantly higher than that of the latter(p<0.05).In the aged group(≥70 years),the level of β_2 m in urine was also significantly in- creased(p<0.001).The results of the study showed that with the inc- rease of age,there was decrease of GER followed by decrease of renal tubular function.It is suggested that this test is more sensitive than traditional methods,such as BUN,Cr and endogenous creatinine clearan ce,and it is more significant in the evaluation of renal function of the aged.