异丙酚在麻醉诱导期的临床作用研究

PREVENTION OF THE CARDIOVASCALEY SIDE EFFECT OF PROPOFOL DURING ANESTHESIA INDACEMENT

目的 为探讨异丙酚预防麻醉诱导、气管插管时的心血管反应。方法 选择 4 0例ASAⅠ～Ⅱ级择期手术患者 ,随机分为两组 ,A(异丙酚诱导 )组和B(硫贲妥钠诱导 )组 ,每组 2 0例 ,分别于术前 30分钟肌注东莨菪碱 0 .3mg ,麻醉给予A组芬太尼、异丙酚和琥珀胆碱诱导 ,B组芬太尼、硫贲妥钠和琥珀胆碱诱导 ,气管插管 ,并记录诱导前、诱导后及插管后 1、3、5分钟的SP、DP、HR、SPO2 和ECG的变化。结果 诱导插管后 ,B组HR与诱导前相比有显著性差异 (P <0 .0 5 ) ,SP、DP与诱导前相比有非常显著性差异 (P <0 .0 1) ,A组虽略有变化 ,但仍在正常范围内。结论 表明异丙酚能明显地减轻气管内插管时的心血管副反应。

Objective To investigate the effects of Propofol on the cardiovascular responses to intravenously and tracheal intubations.Method Forty patients,ASA grade Ⅰ-Ⅱ,scheduled for selective operation under general anesthesia,20 each in control group(Propofol) and general group(Thiopentone Sodium Pentothal),served as the subjects.Scopolamine 0.3mg,30min before anesthesia.Anesthesia was induced with ferctanyl?ropofol/Thiopentone Sodium Pentothal intyavenously and tracheal intubation was facilitated with succinylch oline.SP?DP?HR?Spo2 and ECG were recorded immediately before administration,before intubation 1?3 and 5min after intubation.Result After intraven ously and intu batton,level of HR?SP?DP were hoist in intubatton than those before intubatton in general group (P<0.05).There is a significant difference on these indics between both group(P<0.05 or 0.01).Conclusion Propofol may attenuate obviously cardiovascular responses induced by tracheal intubation.