充血性心力衰竭患者血浆一氧化氮和肿瘤坏死因子含量变化及其意义

Clinical study of changes of plasma nitric oxide and tumor necrosis factor levels in patients with congestive heart failure

目的探讨充血性心力衰竭 ( CHF)患者血浆一氧化氮和肿瘤坏死因子 ( TNF)含量变化及其意义。方法检测 6 8例充血性心力衰竭患者血浆一氧化氮和 TNF含量 ,选择 30例健康体检者作对照组。结果 CHF患者血浆一氧化氮和 TNF水平明显高于对照组 ( P<0 .0 1) ,且心力衰竭程度越重 ,血浆一氧化氮与 TNF水平越高。结论血浆一氧化氮和 TNF增高是 CHF病理生理特征之一 ,一氧化氮与 TNF增高可作为判断心功能级别的一个重要指标。

Objective To study the clinical significance of changes of plasma nitric oxide (NO) and tumor necrosis factor (TNF) levels in patients with congestive heart failure (CHF).Methods Plasma NO and TNF in 68 CHF cases were tested.30 healthy subjects served as normal controls.Results Plasma NO and TNF levels in CHF patients were obviously higher than those in normal subjects (P<0.01).The increase of NO and TNF levels was related to severity of CHF.Conclusion The increase of NO and TNF might be a pathophysiological characteristic of CHF,which can be used as an important index to judge the grading of cardiac function.