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胃癌患者血清中层粘连蛋白和Ⅳ型胶原的表达及临床意义 被引量:2

Expression of seum laminin and collagen type Ⅳ in patient with gastric cancer and clinical implication.
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摘要 目的 探讨胃癌患者血清中层粘连蛋白 (LN)和Ⅳ型胶原 (Ⅳ C)含量的临床意义。方法 应用放射免疫技术测定 2 8例胃癌患者和 30例健康者 (对照组 )血清LN及Ⅳ C含量。结果 胃癌患者血清中LN和Ⅳ C含量明显高于对照组 (P<0 .0 5 ) ;淋巴结转移组血清LN和Ⅳ C含量明显高于无淋巴结转移组 (P <0 .0 5 ) ;胃癌根治术后患者血清中LN和Ⅳ C含量与术前相比明显降低 (P <0 .0 5 )。结论 血清中LN和Ⅳ C含量变化与胃癌细胞的浸润、转移等生物学行为密切相关 ,动态观察对判断胃癌病情。 Objective To evaluate the clinical significance of serum laminin(LN) and collagen type Ⅳ(Ⅳ C) in patient with gastric cancer.Methods Serum contents of LN and Ⅳ C in 28 patients with gastric cancer and 30 healthy volunteers(control group )were measured by radioimmunoassay.Results The contents of LN and Ⅳ C in cancer group were significantly higher than in the control group ( P < 0.05 ).The contents of serum LN and Ⅳ C in the group with lymph node metastasis was higher than in the group without lymph node metastasis ( P < 0.05 ).The contents of serum LN and Ⅳ C in the patients with gastric cancer was significantly decreased after redical operation for carcinoma of stomach as compared with those before operation ( P < 0.05 ).Conclusion The contents of serum LN and Ⅳ C are closely related to tumor invasion and metastasis. The successive detection of contents of serum LN and Ⅳ C might be a simple and useful test for judging the patient's condition and the prognosis of gastric cancer.
出处 《华中医学杂志》 2002年第1期4-5,共2页 Central China Medical Journal
关键词 胃癌 层粘连蛋白 Ⅳ型胶原 外科手术 血清 临床意义 Gastric cancer Laminin Collagen Operation
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  • 1王瑞年,国外医学消化系疾病分册,1993年,13卷,4期,197页
  • 2Ming S C,Cancer,1977年,39卷,6期,2475页

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  • 1刘德萍,邱波.检测胃癌患者血清层粘蛋白和透明质酸的临床意义[J].临床内科杂志,2005,22(9):644-645. 被引量:5
  • 2段秋林,李扬威,石峰,梅雄,郑伦和,段欣,吴健民.联合检测胃液中CEA、CA199、CA242在胃癌诊断中的应用价值[J].肿瘤防治研究,2007,34(8):607-609. 被引量:14
  • 3Dragutinovic ' V,Izrael-Zivkovic ' L,Radovanovic ' N.Relation of matrix metalloproteinase-9 to different stages of tumors in the serum of gastric cancer[J].Dig Dis Sci,2009,54(6):1203-7.
  • 4Ohlund D,Lundin C,Ardnor B,et al.Type Ⅳ collagen is a tumour stroma-derived biomarker for pancreas cancer[J].Br J Cancer,2009,101(1):91-7.
  • 5Mazouni C,Arun B,André F,et al.Collagen Ⅳ levels are elevated in the serum of patients with primary breast cancer compared to healthy volunteers[J].Br J Cancer,2008,99(1):68-71.
  • 6Gao Z L,Zhang C,Du G Y,et al.Clinical significance of changes in tumor markers,extracellular matrix,MMP-9 and VEGF in patients with gastric carcinoma[J].Hepatogastroenterology,2007,54(77):1591-5.
  • 7McDonald J A,Camenisch T D.Hyaluronan:genetic insights into the complex biology of a simple polysaccharide[J].Glycoconj J,2002,19(4-5):331-9.
  • 8Gomez C S,Gomez P,Knapp J,et al.Hyaluronic acid and HYAL-1 in prostate biopsy specimens:predictors of biochemical recurrence[J].J Urol,2009,182(4):1350-6.
  • 9Korenaga D,Orita H,Maekawa S,et al.Peritoneal collagen type IV concentration in adenocarcinoma of the gastrointestinal tract and its relationship to histological differentiation,metastasis,and survival[J].Surg Today,1998,28(8):780-6.
  • 10Pongracz J,Clark P,Neoptolemos JP,et al.Expression of protein kinase C isoenzymes in colorectal cancer tissue and their differential activation by different bile acids Int.Cancer,1995,61:35-39.

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