摘要
目的 探讨胃癌患者血清中层粘连蛋白 (LN)和Ⅳ型胶原 (Ⅳ C)含量的临床意义。方法 应用放射免疫技术测定 2 8例胃癌患者和 30例健康者 (对照组 )血清LN及Ⅳ C含量。结果 胃癌患者血清中LN和Ⅳ C含量明显高于对照组 (P<0 .0 5 ) ;淋巴结转移组血清LN和Ⅳ C含量明显高于无淋巴结转移组 (P <0 .0 5 ) ;胃癌根治术后患者血清中LN和Ⅳ C含量与术前相比明显降低 (P <0 .0 5 )。结论 血清中LN和Ⅳ C含量变化与胃癌细胞的浸润、转移等生物学行为密切相关 ,动态观察对判断胃癌病情。
Objective To evaluate the clinical significance of serum laminin(LN) and collagen type Ⅳ(Ⅳ C) in patient with gastric cancer.Methods Serum contents of LN and Ⅳ C in 28 patients with gastric cancer and 30 healthy volunteers(control group )were measured by radioimmunoassay.Results The contents of LN and Ⅳ C in cancer group were significantly higher than in the control group ( P < 0.05 ).The contents of serum LN and Ⅳ C in the group with lymph node metastasis was higher than in the group without lymph node metastasis ( P < 0.05 ).The contents of serum LN and Ⅳ C in the patients with gastric cancer was significantly decreased after redical operation for carcinoma of stomach as compared with those before operation ( P < 0.05 ).Conclusion The contents of serum LN and Ⅳ C are closely related to tumor invasion and metastasis. The successive detection of contents of serum LN and Ⅳ C might be a simple and useful test for judging the patient's condition and the prognosis of gastric cancer.
出处
《华中医学杂志》
2002年第1期4-5,共2页
Central China Medical Journal