摘要
近年来发现离子通道和突触的慢活动对突触响应和细胞放电以及网络行为有很大的影响 ,进而影响到大脑节律等等 ,成为研究的热点。增强兴奋性慢活动或减弱抑制性慢活动 ,都可使兴奋性突触后电位增大或延长 ,造成突触传递易化 ,引起神经元阵发和网络振荡 ,成为大脑正常和 /或异常节律性活动的基础 ,为进一步揭示大脑的认知和记忆功能以及某些疾病 (如癫 )的发病机制 ,提供了重要的线索。
Recently slow kinetics in ionic channels and synapses have become the hot spots of studying for their prominent effects on responses of synapses, firing modes of neurons, behavior of neuronal networks, and rhythmic activity in the brain. Enhancement of slow excitatory kinetics or depression of slow inhibitory kinetics can augment the amplitudes of EPSPs and prolong the duration of EPSPs, which facilitate synaptic transmissions, evoke bursting of neurons and oscillating of neuronal networks, and furthermore, contribute to normal and/or abnormal rhythmic activity in the brain. It could be a key for understanding the functions of cognition and memory, and the mechanisms of some diseases (such as epilepsy).
基金
国家自然科学基金资助项目 (3 990 0 0 3 7)
