国内40年文献源抗高血压药物不良反应分析

Status of adverse drug reaction of antihypertensive drugs on documents within forty years in China

目的 :了解我国抗高血压药物的不良反应 (ADR)发生情况 ,尤其是一些特殊ADR的情况。方法 :我们收集了国内 4 0a文献源抗高血压药物的ADR资料 ,并加以分析研究。对于个人呈报的ADR报告 ,参照国家卫生部ADR监测中心指定的原则。ADR按世界卫生组织 (WHO)国际药品监测合作中心的药物ADR分类方法分类。结果与结论 :抗高血压药物ADR的发生男性多于女性 ;从年龄结构来看 ,ADR发生集中于 4 5～ 75a年龄段 ,且男性多于女性 ;而 4 5a以下 ,女性多于男性。抗高血压药物的ADR是以心血管系统损害、神经系统损害、精神紊乱、呼吸系统损害为主。抗高血压药物心血管和神经系统损害的ADR中 ,钙拮抗剂占绝大多数 ;

AIM: In order to know the status of adverse drug reaction (ADR) of antihypertensive drugs, especially some special ADR, we have analyses data of ADR of antihypertensive drugs on documents within 40 a. METHODS: According to the principle of Monitor Center of ADR of the Ministry of Public Heath, ADR cases were recorded. ADR cases were put into different categories by the method of International Drug Monitor Center of WHO. RESULTS and CONCLUSION: Men were more then women and aged from 45 to 75; the major ADR were cardiovascular system injured, nervous system injured, mental disorder, respiratory system injured and others; cardiovascular system injured and nervous system injured were caused by calcium channel blockers; respiratory system injured were caused by captopril.