介入性白及凝胶经气道治疗支气管结核的实验研究

The Experimental Study on Treating Bronchial Tuberculoses by Transluminal Hyacinth Blentilla Gel Through Air Passage

目的 :探讨建立介入性白及凝胶经气道治疗支气管结核的方法。方法 :进行耐药结核菌株体外抑菌实验 ;介入性白及凝胶配制实验 ;应用实验犬对该凝胶进行靶支气管灌注、皮下埋藏及口服与支气管灌注药代动力学实验。结果 :提高药物浓度可抑制耐药结核菌株生长 ;得到白及为载体的凝胶剂的配方 ,建立支气管灌注方法学 ;药代显示 :作用时间达60小时以上 ,优于口服给药。结论 :将纤支镜与介入技术、中药白及与抗痨药物相结合 ,在病变的气管、支气管内缓慢释放高浓度抗痨药物 ,以达到治疗目的。

Objective:To found the methodology of treating bronchial tuberculosis by using transluminal hyacinth bletilla gel through air passage.Methods:Some experiments have been done,including the bacteriostasis tuberculosis drug-resistant strain in vitro,preparation of transluminal hyacinth bletilla gel,pharmacokinetics experimnet of perfusion of target bronchus,subcutaneous implantation and oral administration by using transluminal hyacinth bletilla gel in dogs.Two cases are observed.Results:The bacteriostasis tuberculosis drug-resistant strain can be inhibited with the increasing of drug concentration.Dispensing of hyacinth bletilla gel is gained.The methodology of bronchus perfusion is founded.The result of pharmacikinetics shows that bronchus perfusion is better than oral administration after 60 hours.The curative effect is satisfactory.Conclusion:It is an effective method to treat bronchial tuberculosis by using fiberbronchoscope combined with transluminal technology and Chinese herb hyacinth bletilla combined with antiphthisic drugs,which can make the drugs release slowly in trachea and bronchus.