婴儿维生素K缺乏出血症临床研究

The clinical research for the infants with hemorrhage of lacked vitamin K

目的 探讨维生素K缺乏在新生儿及婴幼儿出血中的作用。方法 选择出生～6个月婴儿临床出血病例,维生素K治疗前后检测凝血酶原时间、部分凝血活酶时间及凝血酶原前体蛋白（PIVKA-Ⅱ）进行判断。结果 婴儿维生素K缺乏出血症88例,其中早发型16例占18.2％;典型型10例占11.4％;迟发型62例占70.4％。颅内出血占63.6％,胃肠道出血占22.7％,皮肤出血占20.5％。病死率12.5％。结论 维生素K缺乏出血症目前仍是我国婴儿发病和死亡的重要原因,严重危害婴儿生命健康,应积极有效地开展防治工作。

Objectives To discuss the function of Sacked vitamin K in neonatal and infant hemorrhage. Methods To choose the infants under 6 months with clinical hemorrhage to judge the monitoring prothrombin time, the partial thromboplastin time and the specific target PIVKA-Ⅱ of lacked vitamin K around the treatment with vitamin K. Results There are 88 cases of infants with hemorrhage lacked vitamin K. Among the total cases,16 cases of early found type are 18.2 % ;10 typical cases are 11.4 % ;62 case of late type are 70.4 % . The cases of intracranial hemorrhage are 63.6 % of the total cases; the gastrointestinal hemorrhage is 22. 7 % and the dermatorrhagia is 20.5 %. The mortality of these cases is 12. 5 % .Conclusions At present,the hemorrhage of lacked vitamin K is still the important reason of infant been taken badly and died in our country,which harms severely infant lives and health. We must develop the works of prevention and treatment actively and effectively.