一氧化碳和一氧化氮在婴幼儿肺炎致急性肺损伤中的作用

Plasma carbon monoxide & nitric oxide and acute lung injury in infants caused by pneumonia

目的 探讨一氧化碳（CO）和一氧化氮（NO）在婴幼儿肺炎致急性肺损伤（ALI）中的作用。方法用分光光度法检测27例婴幼儿肺炎致ALI患儿血浆CO、NO水平,并与18例不伴ALI的婴幼儿肺炎对照组和20例健康组作比较。结果ALI急性期血浆CO、NO水平明显高于对照组和健康组（P均<0.01）;与轻度组比较,重度组（ARDS）血浆CO、NO水平显著增高（P均<0.01）;患儿血浆CO和NO水平呈正相关（P<0.01）。结论 内源性CO和NO在ALI的发病过程中具有重要意义。

Objective To explore the role of plasma carbon monoxide(CO) and nitric oxide(NO) in infancies and children with acute lung injury (ALI) caused by pneumonia. Methods The levels of plasma CO & NO in 27 patients with ALI and 18 patients with pneumonia without ALI as control group and 20 healthy infants and children, were measured by spectrophotometry. Results The levels of plasma CO & NO in the patients with ALI were significantly higher than those of the control and healthy group. The levels of plasma CO & NO in the severe group were significantly higher than those in the mild group. The CO levels showed a positive correlation with NO levels. Conclusion The levels of endogenous CO & NO have great significance in ALI.