宫颈分泌物白介素-6和催乳素含量对早产预测的研究

The study of predicting premature delivery of interleukin-6 and prolactin level in endocervical secretions

目的探讨宫颈分泌物白介素 - 6 (IL - 6 )和催乳素 (PRL)的含量与早产的关系 ,研究对早产的预测价值。方法选择孕 2 8～ 36 +6周的早产孕妇 30例作为研究组Ⅰ ;同孕周有早产高危因素的孕妇 2 8例作为研究组Ⅱ ;同期内住院待产的足月孕妇 2 0例作为对照组Ⅰ ;同孕周门诊产检的正常未足月孕妇 2 0例作为对照组Ⅱ进行前瞻性研究。分别取宫颈分泌物后 ,采用双抗体夹心酶联免疫吸附试验检测IL - 6和催乳素含量 ,并分组进行对比分析。结果研究组Ⅰ宫颈分泌物IL - 6及PRL含量与对照组比较P <0 0 0 1;研究组Ⅱ宫颈分泌物IL - 6及PRL含量与对照组Ⅱ比较P <0 0 0 1;早产孕妇宫颈分泌物IL - 6和PRL含量与取样至分娩的间隔时间呈负相关 (r =- 0 5 0 ,P <0 0 1)。结论宫颈分泌物IL - 6和PRL含量与早产密切相关 ;IL - 6和PRL含量的联合检测为早产因素提供了客观、可靠的依据 ,有助于提高早产的预测价值。

Objective A study on relationship of interleukin-6 (II-6) and prolactin (PRL) level in endocervical secretion and premature delivery.Methods 30 cases of premature delivery inpatient at 28～36+5 weeks of gestation were chosen as studying group I and 28 cases of high dangerous factor of premature delivery as studying group II.20 cases of normal term gestation inpatient and 20 cases of corresponding period examined asymptomatic pergnant woman were chosen as control group I and II. The IL-6 and PRL level in each sample were detected by ABC ELISA.Results IL-6 level of studying group I and II were significantly higher than the control group I and II( P <0.001), PRL level of studying group I was significantly higher than control group I and II( P <0.001), Conclusion The increase of IL-6 and PRL level is closely related to premature delivery. The detecting IL-6 and PRL level is valuable in predicting premature delivery.