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γ-氨基丁酸受体亚型和癫痫 被引量：2

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摘要 γ－氨基丁酸（ＧＡＢＡ）受体是脑内普遍存在的抑制性神经递质受体，与癫痫相关的ＧＡＢＡ受体已进入分子水平的研究，尤其ＧＡＢＡＡ受体和ＧＡＢＡＢ受体，以及他们的亚基在癫痫发生和发展中的作用逐渐被人们所认识，并推动了临床抗癫痫新药的开发和利用。
作者 金煜
机构地区 浙江大学医学院附属二院神经科
出处 《国外医学（神经病学．神经外科学分册）》 2002年第1期47-50,共4页 Foreign Medical Sciences（Section On Neurology & Neurosurgery）
关键词 GABA受体 癫痫 γ-氨基酸受体亚型 抗癫痫药
分类号 R742.1 [医药卫生—神经病学与精神病学] R971.6 [医药卫生—药品]
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参考文献17

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同被引文献19

  • 1耿明英,程远,许民辉.神经递质与癫痫的发病机制[J].立体定向和功能性神经外科杂志,2006,19(3):188-192. 被引量：23
  • 2丁成赟,李志梅,王拥军.颞叶癫痫易感基因多态性研究进展[J].国际神经病学神经外科学杂志,2006,33(3):281-284. 被引量：1
  • 3张政,罗勇军,晏宁,晏勇,彭惠民.GABBR1基因G1465A多态与中国汉族青少年肌阵挛癫痫的关系[J].第三军医大学学报,2007,29(15):1488-1490. 被引量：1
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  • 6Nelson RM, Green AR, Lambert DG, et al. On the regulation of is- chaemia-induced glutamate efflux from rat cortex by GABA; in vitro studies with GABA,clomethiazole and pentobarbitone[ J]. Br J Phar- maco1,2000,130 ( 5 ) : 1124 - 1130.
  • 7Green AR, Hainsworth AH, Jackson DM. GABA potentiation : a logical pharmacological approach for the treatment of acute ischaemic stroke [ J]. Neuropharmacology,2000,39(9 ) : 1483 - 1494.
  • 8Peters HC, Kmmer G, Volz A, et al. Mapping, genomic structure, and polymorphisms of the human GABABR1 receptor gene: evaluation of its involvement in idiopathic generalized epilepsy [ J ]. Neurogenetics, 1998,2( 1 ) :47 -54.
  • 9Gambardella A, Manna I, Labate A. GABA (B) receptor 1 polymor- phism (G1465A) is associated with temporal lobe epilepsy[ J]. Neu- rology,2003, 60(4) :560-563.
  • 10Ren L, Jin L, Zhang B, et al. Lack of GABABR1 gene variation (G1465A) in a Chinese population with temporal lobe epilepsy [J]. Seizure,2005,14(8) :611 -613.

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国外医学（神经病学．神经外科学分册）
2002年 第1期

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