黄连素降低血糖的临床观察

Clinical observation on berberine in reducing blood glucose

目的 探讨黄连素降低血糖的作用机制。方法 用分组比较方法对 3 8例非糖尿病者和5 6例糖尿病患者应用黄连素 (0 .8g/次 ,每日 3次 ) 3d后 ,观察血糖和胰岛 β细胞功能。 结果 非糖尿病者用黄连素后血糖无下降 ,同时胰岛素和C肽各时相对应相比无明显变化 ;1型糖尿病患者加用黄连素后血糖无明显变化 ;2型糖尿病患者加用黄连素后血糖较前各时相对应相比有显著下降 (P <0 .0 1)。而胰岛素和C肽无显著增加。结论 本研究提示黄连素能增加 2型糖尿病患者胰岛素的降糖作用 。

Objective To study the mechanism of berberine in reducing blood glucose.Methods The blood glucose and β cell function in 38 non diabetic patients and 56 patients with diabetes mellitus were detected after berberine was orally taken (0.8 g once,three times daily) for three days.Results The blood glucose in non diabetic patients and the patients with type 1 diabetes remained the same,while it was significantly decreased in the patients with type 2 diabetes (P<0.01).The insulin and C peptide in all the patients remained the same.Conclusion Berberine can help insulin to reducing blood glocose,but it can not reduce blood glucose directly.