论氧气法制胍衍生物的化学反应

Discussion on Chemical Reaction of Preparing Guanidine Derivants by Oxygen Oxidizing Process

通过对硫脲衍生物分子化学键的研究 ,发现了氧气法不仅适用于生产二苯胍 ,还适用于生产其他胍衍生物。就是说 ,硫脲衍生物可以通过氧气法制成相应的胍衍生物。氧气法生产胍衍生物的化学反应过程中 ,铜离子的催化作用发生在硫脲衍生物与氧气进行反应生成二氧化硫脲衍生物的反应阶段。铜离子的催化作用表现为消除硫脲衍生物分子母体的共轭π键 ,使硫基π键孤离出来 ,并使硫基极化。本文讨论硫脲衍生物分子母体的化学键及其变化 ,叙述氧气法制胍衍生物的化学反应。

Oxidative methods to prepare not only 1,3-Diphenyl guanidine but also other guanidine derivants were introduced through studying chemical bonds of thiourea derivants in this paper. Namely, guanidine derivants can be prepared from corresponding thiourea derivants by oxidative methods. Preparing guanidine derivants from thiourea derivants, catalysis of cupric ion occured in the reaction of oxygen and thiourea derivants. The catalysis of cupric ion was to eliminate the conjugated pi bonds in the thiourea derivants molecules and seperate the thio-group pi bonds and polarize the thio-group. Chemical bonds and their variation in thiourea derivants were discussed.